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The findings underscore the potential of GLP-1 RAs in treating CNS-related conditions while identifying critical gaps in current knowledge that warrant further investigation

These strategies achieve active manipulation of ROS generation pathways by directionally amplifying oxidative pressure in lesion areas

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It incorporates aminoisobutyric acid (Aib) at the N-terminus, D-isomers at positions 3 and 4, and C-terminal amidation, which together confer metabolic stability and selective receptor activation

Since GLP-1R agonists are known to greatly modulate and reduce intracranial pressure, we therefore hypothesized that these drugs could be effective in migraine, he said