Inhibition of the JAK/STAT3 pathway is an important strategy for improving UC
International Journal of Molecular Sciences, 19 (7), 1987
Many people with Crohns live full, active lives
Several factors can impair B12 absorption: Reduced stomach acid production (achlorhydria or hypochlorhydria), common in older adults and those taking proton pump inhibitors or H2-receptor antagonists long-term, impairs the release of B12 from food proteins Pernicious anaemia , an autoimmune condition destroying parietal cells and reducing intrinsic factor production, completely blocks the primary absorption pathway Gastrointestinal disorders including Crohn's disease, coeliac disease, or surgical removal of stomach or ileum sections directly damage absorption sites Metformin , commonly prescribed for type 2 diabetes, may reduce B12 absorption through unclear mechanisms
In the context of weight loss, a study showed that participants taking semaglutide lost a significant amount of weight over 68 weeks compared to those given a placebo
