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[1,11] For this reason, the treatment is unsuitable if your personal or family medical history includes MTC or MEN 2 (Multiple Endocrine Neoplasia syndrome type 2)
Overall, although there were accounts suggesting a potential risk of renal damage with tirzepatide, the SURPASS-4 trial and the additional study (Clinical Trials NCT03482024) indicate favorable effects on renal function,involving a decrease in the rate of eGFR decline and a decreased incidence of the composite kidney endpoint [80, 81]
These effects are thought to be related to anti-inflammatory and antioxidant processes in the brain, as well as changes in neurotransmitters involved in mood regulation
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