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Serum samples were diluted three times with normal saline before analysis
Consistent with previous studies, cotadutide outperformed GLP-1 alone (40 nmol/kg/day liraglutide) in achieving maximal weight loss in obese mice, and this was attributed to the increased energy expenditure (77)
Greater decreases in postprandial glucose levels were observed with exenatide than with liraglutide or exenatide LAR [17,76]
doi:10.1016/j.bbr.2019.112359 84
The crude material was purified by automated flash column chromatography on silica via gradient elution, from 100% dichloromethane to 1% methanol in dichloromethane to produce SS(NHS-CM) 2 (979 mg, 79%) as an off-white foamy solid
