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Nature Health, 10 April 2026

Current Version May 15, 2024 Written By Jake Peter Fact-checked By Dr

Frequently Asked Questions What weight-loss ranges does this article attribute to the STEP and SURMOUNT trial programs

Gastrointestinal Function Studies Ipamorelins ghrelin-mimetic properties have been studied in gastrointestinal motility research: Dose-dependent improvement in gastric emptying in rodent postoperative ileus models Enhanced gastrointestinal contractility through cholinergic neuron activation Accelerated recovery of bowel function in experimental surgical models Effects mediated through ghrelin receptor activation in enteric nervous system Phase II human trials investigated ipamorelin for postoperative ileus treatment, though results did not reach statistical significance for primary endpoints

Proceptive behaviors in the female rat include ear wiggling, hopping, darting around the male, and approaching and withdrawing movements