Universal response: 100% of participants on 812 mg achieved at least 5% weight reduction [4]
The trial tested multiple dose levels over 48 weeks, and the headline result, up to 24.2% body weight reduction at the highest dose, grabbed international attention
When combined with lifestyle modifications, patients can lose an average of 15% of their body weight
In IPF, environmental factors such as cigarette smoke, air pollution, and microbial infections damage alveolar epithelial cells (AECs) and microvascular endothelial cells, initiating an aberrant injuryrepair cascade [33,34,35]
This drug class was therefore tested as a weight losing intervention in individuals with overweight and obesity without type 2 diabetes