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A phenotype beneficial in one disease stage or anatomical region may prove deleterious in another

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piezogenic papules) Edema in the legs in the absence of cardiac failure Mild proximal and distal muscle weakness Axonal polyneuropathy Atrophy of muscles in hands and feet Acrogeric hands, mallet finger(s), clinodactyly, brachydactyly Vaginal/uterus/rectal prolapse Dermatosparaxis EDS (dEDS) If a person meets the diagnostic criteria for dEDS, genetic testing should be done to confirm the diagnosis

Small molecule inhibitors of mammalian thioredoxin reductase as potential anticancer agents: an update

J Nephropathol