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Mechanism-informed patient selection Biomarker-based stratification: Identifying patients most likely to respond based on mechanistic markers

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The phase 3b, open-label, randomized controlled trial enrolled 751 adults with obesity or overweight plus at least one weight-related comorbidity such as hypertension, dyslipidemia, or sleep apnea

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Discussion Since the discovery that the LS is a potent site of electrical self-stimulation in both rodents and humans, 20, 71 it has historically received relatively little attention as a reward center