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The consistency of positive outcomes across diverse animal studies suggests real therapeutic potential, while the lack of large-scale human trials means optimal protocols remain somewhat empirical

Zhang X, Zhang R, Chen H, Wang L, Ren C, Pataer A, Wu S, Meng QH, Ha MJ, Morris J, Xi Y, Wang J, Zhang J, Gibbons DL, Heymach JV, Meric-Bernstam F, Minna J, Swisher SG , Roth JA, Fang B

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[8] Cagrilintide, by contrast, is not approved for any indication anywhere

Each format has tradeoffs that map onto where the user is in the staged titration protocol