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The broader lesson from the oral secretagogue MK-677, which raised IGF-1 durably yet did not translate into unambiguous functional gains in key trials, is a cautionary reference point for the whole class
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Moreover, the limitations of animal models in translating findings to human addiction underscore the need for caution, since results may not always directly apply to humans
The clinical trials above used full-length Thymosin Beta-4, not TB-500 specifically
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