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Several physicians also reported prescribing GLP-1RAs for additional off-label uses, including chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), and idiopathic intracranial hypertension

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Phase 2 clinical research published in 2023 documented metabolic effects exceeding those reported for any prior incretin agonist, establishing retatrutide as a benchmark reference compound for triple-receptor pharmacology and as a focal point for the next generation of metabolic peptide research

doi: 10.1016/j.breast.2023.01.003

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