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The approval is supported by results from the Phase 3 POETYK PsA1 and POETYK PsA2 trials, which demonstrated statistically significant improvements in ACR20 Response and other key disease outcomes compared with placebo, while maintaining a safety profile consistent with earlier studies

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Tissue-bound peptide activity persists significantly longer

They are released in response to food, signaling the pancreas to release insulin and slowing gastric emptying