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These initiatives illustrate how short-term supply shortfalls persist despite huge investments , since biologic and peptide APIs require long lead times and sophisticated facilities to scale ( [12] ) ( [5] )
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Effectiveness estimand refers to the effect before stopping the study drug or starting rescue therapy to treat persistent severe hyperglycemia
When systemic mitochondrial dysfunction occurs, the neurological consequences are severe
Treatment with 3,3-dimethyl-1-butanol, an inhibitor of TMA formation, prevented these effects
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