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[16] [19] Subsequent analysis of SUSTAIN-6 data revealed that the increased risk was concentrated among patients who entered the trial with pre-existing diabetic retinopathy and experienced rapid improvements in glycemic control

They first came out with a medication that was twice daily dosing, and then they reduced that to once daily dosing, and now we are once a week

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Standard titration schedules are already designed to minimize side effects by starting at a low dose and increasing gradually

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