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10.1385/JMN:18:1-2:07 104

HDAC5 depletion leads to heterochromatin disorganization, genomic instability, and DNA damage responses that trigger autophagy and apoptosis

Most people have nausea and occasionally vomiting or other GI side effects like diarrhea. Other side effects can include constipation, abdominal pain, and upset stomach or indigestion