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This level of sensitivity requires continuous method optimization and forced degradation studies

G., Lee, B.-R., Koprivova, A., Matthewman, C

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Further, biomarker concentrations are tricky to interpret: Total GSH concentration often fails to accurately reflect redox balance, which is better indicated by the GSH to GSSG ratio, plasma/serum concentrations are often a weak correlate of tissue level (the locus of action), and compartmentalization within cells (cytosol versus mitochondria) adds another layer of complexity often out of grasp in clinical samples [31]

Ultimately, your provider will help you weigh the pros and cons and determine the next best step for your individual situation