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Additionally, certain medications can counteract GLP-1 effectsfor example, corticosteroids can raise blood glucose levels, whilst some psychiatric medications may increase appetite or promote weight gain

The SULT genes help with phase II detoxification of estrogens, neurotransmitters, certain carcinogens, and steroid hormones

Journal of Trace Elements in Medicine and Biology, 88 , 127603

As visceral fat increases, men may become more insulin resistant, which can encourage further fat storage and make weight loss more challenging, even with a consistent diet and exercise

1 OASIS 4 included a 64-week treatment period, including a 12-week dose escalation, and a 7-week off-treatment follow-up period