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When used alone, especially in higher doses, the GLP-1s regularly cause loss of muscle and bone (lean body mass)
Important safety considerations include risks of acute pancreatitis (seek medical attention for severe abdominal pain with or without vomiting), gallbladder disease, dehydration, and potential worsening of diabetic retinopathy with rapid improvement in glucose control
Medication orders lacking structured information on total days supplied were excluded, as these were frequently free-text entries unsuitable for reliable longitudinal analysis
In experimental models, researchers may explore processes such as receptor-mediated signaling, pulsatile hormone release dynamics, and downstream metabolic pathway modulation
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