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This effect was narrowed down with the application of seeds pretreated with 50 mM NaCl to about 123% in root and 152% in shoot of arhar seedlings, 17% in root and 16% in shoot of maskalai seedlings and 14% in root and 8% in shoot of khesari seedlings compared to non-pretreated control

That said, outside of certain sensitivities, allergies, or medical conditions, it's extremely difficult to take "too much" vitamin B12

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8 clarified that the increase in ROS reaches a threshold level activating the mitochondrial permeability transition pore (mPTP) opening, which in turn leads to the simultaneous collapse of and a permanent increase in ROS production by the electron transfer chain, resulting in a decrease in cell viability