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The many types of intranasal nanoparticles being developed (polymeric, solid lipid, microemulsions and nanoemulsions, polymeric micelles, nanonstructured lipid carriers, polymer-lipid hybrid, chitosan and PGLA nanoparticles) speak to the richness of this drug delivery field

There are no FDA-approved weight-loss IVs

Semaglutide carries a warning about potential worsening of diabetic retinopathy, particularly in patients with pre-existing retinopathy and rapid improvement in glucose control

Sulfur metabolism under stress

Unlike semaglutide tablets that require the SNAC enhancer, orforglipron has much higher oral bioavailability as a small molecule