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Stratification of astrocytes in healthy and diseased brain
Statistical analysis A sample size of 156 participants (104 randomized to survodutide and 52 to placebo) was calculated to provide 90% overall power to demonstrate superiority of survodutide 6.0 mg over placebo for both co-primary endpoints, each at a two-sided significance level of 0.05, assuming an early treatment discontinuation rate of 15%
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