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No deficiency, no predictable energy benefit NIH and Mayo Clinic note that B12 supplementation has not been shown to improve energy, endurance, or athletic performance in people whose B12 status is already sufficient
Theoretical Concerns From Mechanism While NNMT inhibition is a promising research target, the mechanism raises points that warrant caution in interpretation
Mistake #1: Underdosing Using 100-150mcg thinking it saves money
Age: absorption naturally slows as we get older, so timing can shift over the years
