10.3390/antiox13121578 77 RybakL
The best evidence for weight loss comes from a meta-analysis of 37 trials: a modest average reduction of about 1.2 kg (under 3 lbs), mostly in adults who are overweight
Each compound is supported by decades of published research from independent research groups
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These include orlistat, liraglutide, and semaglutide (NICE TA875 for weight management in adults with obesity), as well as GLP-1 receptor agonists within the framework of NICE NG28 (type 2 diabetes management)