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The Results: Breaking Down 28.7% Weight Loss Primary Efficacy Outcomes Both retatrutide doses met all primary and key secondary endpoints with statistical and clinical significance: The 12mg dose achieved the highest weight loss on record for a Phase 3 obesity trial, with more than 1 in 4 pounds lost from baseline body weight

Clinical trial data from the STEP 1 and SURMOUNT-1 trials show that patients typically achieve 1015% total body weight loss with semaglutide 2.4 mg weekly (Wegovy) and 1520% with tirzepatide 1015 mg weekly (Zepbound) over 1218 months

This guide covers everything you need to know before combining these two strategies

For general health purposes, consistency matters more than timing