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In an interview with People magazine in December 2023, when she revealed she uses weight loss medication as a maintenance tool, Oprah recounted how she began using them

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When food reaches the small intestine, hormones including GLP-1 are released which in turn enhances insulin secretion in the pancreas, slows gastric emptying and suppresses hunger by inhibiting the release of glucagon, a hormone involved in hunger regulation

Amersis protocol involves gradual increases over seven or more weeks, with lab monitoring at each stage