Endocrinology Targeting the central melanocortin system for the treatment of metabolic disorders 2023 DOI: 10.1038/s41574-023-00855-y PMID: 37365323 Sweeney P, Gimenez LE, Hernandez CC, et al
This distinction matters because abnormal glucose, liver enzymes, kidney markers, lipids, or nutritional markers may predate semaglutide use
Given the documented effects of GLP-1 and GLP-2 on rodent liver regeneration and their routine therapeutic targeting for other indications, we sought to explore perioperative dynamics of GLP-1 and GLP-2 in patients undergoing hepatic resections
It may be important to include measurements of biomarkers of oxidative damage (e.g., products of DNA and lipid oxidation, such as 8-hydroxy-2-deoxyguanosine, 8-OHdG, or F 2 -isoprostanes) in observational studies, suggesting that the therapeutic benefit may actually be associated with an antioxidant effect (Moosmann and Behl, 2002
Mendelian randomization evidence indicates that elevated KYN levels have a causal relationship with increased risk of depression, with each standard deviation increase in KYN corresponding to ~ 1.4-fold higher odds of developing depression [50]
