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As a result, this reduction often reflects in the skin in the form of dullness, uneven tone, and early signs of aging
The maintenance frequency approach represents hybrid strategy where initial intensive treatment (daily application for 3-6 months) establishes improvements, then reduces to maintenance schedule (2-3 times weekly or every other day) rather than complete discontinuation
GHK exists naturally in saliva and urine as well, released from extracellular matrix proteins including SPARC and the collagen 2(I) chain during tissue injury, functioning as a matrikine damage signal that activates repair mechanisms
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