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The STEP-1 trial demonstrated mean weight loss of 14.9% with semaglutide over 68 weeks, while the SURMOUNT-1 trial showed tirzepatide achieving 16-22.5% weight reduction over 72 weeks
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Common pitfalls with traditional methods are: Probes lack specificity, reacting with multiple reactive species and generating ambiguous results Measurements require specialized instruments or complex sample preparation Results are difficult to quantify and reproduce between experiments Questions & Solutions Is glutathione redox balance shifting
The choice of secretagogue shapes which of those variables stays quiet and in study designs where prolactin is part of the background biology, the compound selection has direct consequences for interpretation
The FDA decision is anticipated in 2H2025
