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it profoundly affects the autonomic nervous system (ANS) and cardiovascular function
When NAD+ falls, mitochondrial output drops, and patients typically describe fatigue that does not respond to sleep, sluggish recovery from workouts, low motivation and reduced stamina
(PubMed) Bustamante J, Lodge JK, Marcocci L, Tritschler HJ, Packer L, Rihn BH
Not because the symptoms are mild
Most adjustment-related headaches resolve completely by week three, and many patients report improved energy and mental clarity once the initial side effect window passes
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