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People with type 2 diabetes or obesity may also have insulin resistance , which occurs when cells stop responding as well to the hormone insulin

If you stop tirzepatide and wait two weeks (roughly four half-lives) before starting retatrutide, the previous medication will have largely cleared, and you are starting closer to baseline

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This means hydroxyzine (25-50mg) for oral sedation and ondansetron (4mg) for intravenous sedation