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They are sometimes prescribed off-label, but you should consult your healthcare provider to determine if it is a safe option
The exploration of combination with resmetirom, the first FDA-approved agent specifically for MASH, embodies a particularly interesting avenue given the complementary mechanisms of action [71]
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What the data supports: Retatrutide produces substantial, dose-dependent weight loss The 12mg dose shows the highest efficacy but also the most side effects Slow dose escalation (starting at 2mg) significantly improves tolerability Liver fat reduction is dramatically superior to existing drugs Knee OA pain improves substantially with weight loss on retatrutide Cardiovascular risk markers (cholesterol, blood pressure, inflammation) improved in trials What we dont know yet: Long-term safety beyond ~68 weeks What happens to weight after stopping (no retatrutide-specific data yet) Whether weight loss is primarily fat vs
[85] [86] Even if such data are interesting from a scientific point of view, the application in the clinical routine of a prognostic model based on specific genotypes is still not possible
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