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In obesity, however, this finely tuned signaling system often becomes impaired, leaving the brain in a persistent state of hunger even when the bodys energy stores are already sufficient
What the trials measured is lean mass loss that accompanies rapid weight loss, which is a normal response to a large calorie deficit in anyone losing weight
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In the liver-fat substudy, beta-hydroxybutyrate, a marker of fat being burned for fuel, rose two to threefold at the higher doses
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