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Also, GLP-1R agonists can protect the heart and kidneys, reduce the risk of cardiovascular events, and delay the progress of diabetic nephropathy, which is especially important for people with diabetes

Ms all de la va de cAMP cannica, la activacin de GLP-1R por tirzepatide ha sido asociada con el reclutamiento de andamios -arrestina y dinmicas de internalizacin que difieren de las de agonistas selectivos de GLP-1R, ofreciendo una dimensin mecanicista relevante para la investigacin de la desensibilizacin de receptores y el agonismo sesgado