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These included the -opioid (Cvejic and Devi, 1997), metabotropic glutamate (Romano et al., 1996), and 2 adrenergic (Hebert et al., 1996) receptors
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Long-term treatment with these antibiotics increases the excretion of pivaloyl-carnitine, which can lead to a lack of carnitine
Another important factor was it had the capacity to bind to albumin, a large protein common in the bloodstream, which would make the GLP-1 molecule too large to be quickly cleared by the kidney
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