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For musculoskeletal injuries, subcutaneous is preferred because it delivers higher local concentrations
24 APPswe/PSEN1-dE9 transgenic, aged from 1214 months old) and 2 Wild-type (C57BL/6) male mice were employed (bred from the Department of Physiology, Taipei medical university, Taiwan)
GHK-Cus tissue-level changes build progressively over weeks and months
2009;297(2):L388-400
This has called for new emerging strategies for improved bioavailability that include chemical modifications to stabilize the peptide, use of enzyme inhibitors, linkage to absorption enhancers, and packaging peptides using nanoparticles
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