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In addition to its pro-differentiating actions, nicotinamide promotes neuronal survival, especially in oxidative stress environments, through various pathways, such as maintenance of protein kinase B (akt)-dependent phosphorylation of forkhead transcription factor (FOXO3a)

GSTP1-775 knockdown cells (A2780/GSTP1) were therefore selected for use in additional experiments, following additional confirmation of increased total cellular glutathione levels (A2780 83.161.67 M and A2780/GSTP1 116.854.67 M), consistent with reduced GSTP1 catalytic activity

Advanced: 4 to 8 mg/week, often split across two injections