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Intense exercise increases cortisol, can trigger compensatory hunger, and may not produce the expected caloric deficit because the body adapts
Chao T.F., Hung C.L., Tsao H.M., et al
Cecal levels of Akkermansia muciniphila have been strongly correlated with physiological metrics including glycemia and insulinemia 89 , and Akkermansia has correlated negatively with obesity-related measures 90 and has been implicated in DIO prevention 91,92
Additionally, some SSRIs, including sertraline, may cause modest weight changes in either direction during long-term use