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There isn't enough research to say for certain how safe GLP-1 patches are, which is one of the main concerns around them

Lancet 1971;1:519-22 Rumack BH,Mathew H,Acetamenophen poisoning and toxicity.peddiatrics 1975;55:871-6 Daly FF, Fountain JS,Murray L,Graudins A,Buckley NA,Guidelines for the management of paracetamol in Australia and New Zealand- explanation and elaboration.A consessus statement from clinical toxicologists consulting to the Australasian poisons information centres

To measure oxidative stress, the study evaluated nine different biomarkers: ammonia, beta-carotene, glutamine, glutathione, malondialdehyde, total antioxidant status (TAS), vitamin C, vitamin E-alpha tocopherol, and vitamin E-gamma tocopherol

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