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GSH has long been implicated as a major antioxidant and redox regulator that functions to mitigate and alleviate this oxidative damage ( However, the preceding sections of this paper establish that GSH is not merely a passive antioxidant, but an immune regulator and modulator with actions dependent upon the pathophysiologic context (Ghezzi, 2011) GSH acts to regulate the thresholds necessary for immunologic activation through redox-sensitive signal transduction pathways, influences antigen presentation and the development/differentiation of immune cells, and modulates the production of cytokines

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This gene modulation capability extends to shifting gene expression in COPD lungs from a destructive state to one of healthy remodeling, showcasing its broad therapeutic potential 13

Savikj M, Stocks B, Sato S, Caidahl K, Krook A, Deshmukh AS, et al

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