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When you eat foods high in sugar or fat, their impact on your digestive system can intensify, potentially leading to diarrhea and vomiting

When you add a GLP-1 medication like semaglutide injection to this picture, you create opposing forces working on your glucose metabolism simultaneously

Why this matters: The findings suggest that GLP-1-based medications may play a meaningful role in managing heart failure in people with obesity, though the smaller trial size means further research is needed to confirm these results

GLP-1 is a hormone your body makes naturally, one of several that helps regulate your appetite

"So that seems to happen, and we see it with bariatric [obesity-management] surgery too." Rubino says that some people can regain weight after quitting semaglutide, but still retain some of the metabolic health benefits achieved while taking the drug, such as improved blood sugar control