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B12 is water-soluble and any excess is excreted in urine there is no established upper tolerable intake level for B12 and toxicity from injection at standard doses has not been reported
Inflammopharmacology 31 (1), 221230
The method involved intracellular oxidation of non-fluorescent dye dihydrorhodamine-(DHR)-123 to the fluorescent rhodamine-123 (R123) caused by free radicals and hydrogen peroxide