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These findings may reflect an increased requirement for carnitine supplementation, particularly in individuals with PKU who have higher metabolic demands (Weigel et al., 2008)

This is an important consideration for future studies due to the larger effect size in risk of PDAC observed in patients with new onset compared with longstanding diabetes (typically defined as 3 years duration) 46

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In the UK alone, some half a million people are now thought to access them through private prescriptions each paying around 200 a month to do so