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LEADER trial (Marso 2016, PMID 27295427) reported 13% reduction in MACE in T2D patients with high cardiovascular risk

SUMO2 and SUMO3 interacted and modified several AR-associated coregulators (p300, SRC2, BAF proteins) and pioneering factors (FOXA1, HOXB13) associated with ARE-bound AR, demonstrating that SUMOylation amplified interactions with its transcriptional complex

The most common side effectsmild nausea, reduced appetite, and occasional gastric discomfortdepend more on your total weekly dose and individual tolerance than on minor timing shifts

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Good sources include chicken, fish, eggs, turkey, tofu, shrimp, and Greek yogurt