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The TriNetX platform has been used in retrospective cohort studies [25,26,27,28,29,30,31,32,33,34,35,36,37,38] including evaluating risk and health outcomes of patients with substance use disorders including CUD [25, 32, 35] and the associations of GLP-1RAs with cancer [37] and semaglutide with suicidal ideations [38]

The LCIG application caused changes in the beta diversity (which assesses the differences in microbial community composition between samples, indicating how similar or dissimilar microbial communities are across individuals or time points)

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