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Structural and functional studies have shown that Lig4 interacts with XRCC4 through an extended region comprising the linker between the two Lig4 BRCT domains (-hairpin region (amino acids 759770) and Helix1-Loop-Helix2 clamp domain (amino acids 771803), both forming a minimal XRCC4 interacting region thereafter named XIR) followed by a portion of the second Lig4 BRCT domain (BRCT2) 16,22,25 (Fig

[PMID: 21152927] PubMed record related to this compound for laboratory literature review

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Stem Cells 35 (4), 851858

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