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Identification of the proteoglycan binding site in apolipoprotein B48
Pfizers candidate, danuglipron, emerged after screening 2.8 million compounds against a GLP-1 receptor to which another compound was already bound outside the target site, changing its shape and rendering it more sensitive
The reactions reported ranged from relatively mild findings to less common but more significant skin reactions
Slow cumulative change is almost impossible to see without reference images
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