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Both medications are taken as once-weekly subcutaneous injections and work best alongside a reduced-calorie diet and regular physical activity

The 4-week standard applies to both injectable and oral GLP-1 formulations, though some anesthesiology teams may adjust based on your specific medication, dose timing, and type of surgery

not FDA-approved and not therapeutically equivalent to Mounjaro or Zepbound Ro offers a broader medication catalog, including FDA-approved brand options As of July 2026, Ro has fully exited compounded GLP-1s and provides access only to FDA-approved brand-name medication paths through its membership platform

Consistency Over Timing While the specific hour you take the medication doesnt matter relative to your meals, consistency does matter for your overall results

Mathematically, a 10mg vial contains enough semaglutide for the first 16 or more weeks of escalation at the standard schedule