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9,10 Additionally, GLP-1 RAs suppress glucagon secretion from the -cells in the pancreas, leading to decreased blood glucose levels

They are also at greater risk of muscle loss during weight loss, which has more severe consequences for mobility, bone health, and independence than it does for younger populations

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Consideration should also be given as oral semaglutide has been associated with greater discontinuation of treatment in patient groups aged 65 years or older (Filippatos et al., 2014