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A number of potential alkylating agents, such as N-ethyl maleimide, led to loss of reactive sulfur, and thus the field has focused on iodoacetyl 28 or monobromobimane derivatives 28,34,35 , although some concerns remain about the inadvertent loss of the reactive sulfur 36
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Cecarini V, Bonfili L, Cuccioloni M, Keller JN, Bruce-Keller AJ, Eleuteri AM
Genazzani AD, Despini G, Czyzyk A, Podfigurna A, Simoncini T, Meczekalski B
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