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The adjustment of microbiota leads to the production of N, N-dimethylsphingosine (DMS), which promotes intestinal IL-22-producing ILC3s and alleviates colonic inflammation (Sun et al., 2024)
Forest plot of GLP-1 receptor agonists versus comparators on the risk of Pulmonary hypertension
Cons: Side Effects: Can cause nausea, gastrointestinal discomfort and headaches in some individuals
Sodium-glucose co-transporter 2 (SGLT2) inhibitor canagliflozin suppresses TECs apoptosis via maintaining metabolic homeostasis (119), while boeravinone C, an PPAR activator/agonist, can alleviate lipid accumulation and inflammation, thereby suppressing tubular apoptosis (120)
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